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| Case # 1 |
| Customer : |
Big Pharmaceutical Company |
| Process : |
7- Stage chiral compound with one column chromatography |
| Deliverables : |
Find a new scalable route
Delivery of 1 Kg with chiral purity NLT 98% ee |
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| Team : |
3 Process Chemists & 1 Analytical Chemist |
| Work Done : |
New routes identified
One route (4 steps) taken up for development - avoids column chromatography
Chiral induction using Evans asymmetric strategy
Successfully completed feasibility & optimization
Chiral auxiliary recovery |
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| Result : |
Enhanced chiral purity > 99 % ee
Fewer steps & recovery of chiral auxiliary made the process economical
Delivered 1 Kg within timelines – 4 months |
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| Case # 2 |
| Customer : |
Big Pharmaceutical Company |
| Process : |
No technical package available.
Final compound known to be unstable - Liquid |
| Deliverables : |
Scalable process
Delivery of 10 Kgs |
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| Team : |
4 Process Chemists, 1 Analytical Chemist & KL manufacturing |
| Work Done : |
Two new routes identified
Both taken up for laboratory feasibility; 5 Step process is finalized
Resolved issue of regio-isomer and stability issue by making salt
Process taken for scale up
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| Result : |
Robust and scalable process
Delivered 10 Kgs within timelines – 5 months
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| Case # 3 |
| Customer : |
Big Pharmaceutical Company |
| Process : |
Technical package available |
| Deliverables : |
Delivery of 200 Kgs meeting specifications |
| Team : |
3 Process Chemists, 1 Analytical Chemist & manufacturing |
| Work Done : |
5 chemical conversions and 2 isolated stages from commercially available raw materials
7% overall yield improvement
Technology transferred to plant
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| Result : |
On Time In Full Delivery - 3 months
Three reload campaigns – 200 Kgs & 2 X 950 Kgs
Developed two new vendors for critical raw material |
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